37 Results for "

Astragalus caprinus L.

" in MedChemExpress (MCE) Product Catalog:
Products (37)

37 Results for "Astragalus caprinus L." in MCE Product Catalog:

35
Astragaloside IV
Astragaloside IV
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35 Publications Verification
Cat. No.: HY-N0431
CAS No.: 84687-43-4
Category:  

Triterpenes Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Cancer

Target:  

MMP ERK JNK

Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
2
Rhamnocitrin
Rhamnocitrin
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2 Cited Publications
Cat. No.: HY-N1353
CAS No.: 569-92-6
Category:  

Cardiovascular Disease Flavonols other families Flavonoids Phenols Polyphenols Plants Disease Research Fields

Target:  

p38 MAPK

Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
2
Astragaloside III
Astragaloside III
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2 Cited Publications
Cat. No.: HY-N0434
CAS No.: 84687-42-3
Category:  

Triterpenes other families Leguminosae Terpenoids Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields

Target:  

C-type Lectin-like Receptors (CTLRs) Apoptosis Dengue Virus

Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces TACE phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer .
2
Methylnissolin-3-O-glucoside
Methylnissolin-3-O-glucoside
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2 Cited Publications
Cat. No.: HY-N2473
CAS No.: 94367-42-7
Category:  

Flavonoids Leguminosae Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Inflammation/Immunology Other Flavonoids

Target:  

Others

Methylnissolin-3-O-glucoside (Methylnissolin-3-O-β-D-glucoside) is a flavonoid from the roots of Astragalus membranaceus with anti-inflammatory effects .
2
Isoastragaloside I
Isoastragaloside I
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2 Cited Publications
Cat. No.: HY-N0887
CAS No.: 84676-88-0
Synonyms: Isoastragaloside-I
Category:  

Triterpenes other families Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Metabolic Disease Plants Disease Research Fields

Target:  

Akt NF-κB p38 MAPK PI3K FXR Keap1-Nrf2 NO Synthase COX Interleukin Related Integrin TGF-β Receptor Reactive Oxygen Species (ROS)

Isoastragaloside I is a natural compound found in Astragalus membranaceus, with oral activity and multiple biological activities such as anti-inflammatory and antioxidant properties. Isoastragaloside I inhibits Akt, NF-κB, MAPKs and PI3K, enhances the activity of hepatic FXR, regulates the TGF-β/Smads signaling pathway, and upregulates antioxidant molecules downstream of Nrf2. Isoastragaloside I inhibits the expression of NO, TNF-α, iNOS, COX-2, IL-1β and VCAM-1, and reduces intracellular ROS levels. Isoastragaloside I attenuates blood-brain barrier disruption, restores intestinal barrier function, increases β-cell mass, improves glucose homeostasis, and elevates circulating adiponectin levels. Isoastragaloside I can be used for the study of neuroinflammation-related neurodegenerative diseases, cholestatic liver disease, and diabetes .
1
Astragaloside II
Astragaloside II
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1 Cited Publications
Cat. No.: HY-N0433
CAS No.: 84676-89-1
Synonyms: Astrasieversianin VIII
Category:  

Triterpenes Leguminosae Terpenoids Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields

Target:  

Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB

Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .
Astragaloside I
Astragaloside I
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Cat. No.: HY-N0432
CAS No.: 84680-75-1
Synonyms: Astrasieversianin IV; Cyclosieversioside B
Category:  

Triterpenes other families Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Metabolic Disease Plants Disease Research Fields

Target:  

Wnt β-catenin

Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through activating the Wnt/β-catenin signaling pathway .
Polysachoride of astragalus mongholicus
Polysachoride of astragalus mongholicus
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Cat. No.: HY-159066
Purity:  70.29%
Polysachoride of astragalus mongholicus is an astragalus polysaccharide that can be isolated from Astragalus Mongholicus, exhibits antifibrotic activity .
Astragaloside IV (Standard)
Astragaloside IV (Standard)
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Cat. No.: HY-N0431R
CAS No.: 84687-43-4
Category:  

Triterpenes Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants

Target:  

Reference Standards MMP ERK JNK

Astragaloside IV (Standard) is the analytical standard of Astragaloside IV. This product is intended for research and analytical applications. Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
Cyclogalegenin
Cyclogalegenin
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Cat. No.: HY-N0424
CAS No.: 84605-18-5
Synonyms: Cyclogalegigenin
Category:  

Triterpenes Leguminosae Anti-aging Terpenoids Other Diseases Plants Disease Research Fields Astragalus galegiformis

Target:  

Others

Cyclogalegenin (Cyclogalegigenin) is an isoprenoid. Cyclogalegenin can be isolated from Astragalus galegiformis. Cyclogalegenin is an isomer of cycloastragenol.
Tragacanth gum
Tragacanth gum
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Cat. No.: HY-W250121
CAS No.: 9000-65-1
Tragacanth gum is an orally active anionic composite polysaccharide and multifunctional biomaterial. Tragacanth gum exhibits biocompatibility, mucoadhesion and renoprotective effects, and effectively promotes wound closure and tissue healing. Tragacanth gum can be isolated from Astragalus gummifer. Tragacanth gum acts as an emulsifier and drug delivery carrier, and is also widely used in fields such as 3D scaffolds, tissue engineering and green nanoparticle preparation. High doses of Tragacanth gum may induce reversible forestomach squamous epithelial hyperplasia in mice, but show no mutagenic or carcinogenic activity. Tragacanth gum is commonly used in studies related to diseases including systemic candidiasis, rheumatoid arthritis and osteosarcoma .
Isoastilbin
Isoastilbin
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Cat. No.: HY-N4005
CAS No.: 54081-48-0
Category:  

Flavanonols other families Flavonoids Phenols Polyphenols Plants

Target:  

Bacterial Tyrosinase

Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .
Isoastragaloside II
Isoastragaloside II
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Cat. No.: HY-N0888
CAS No.: 86764-11-6
Synonyms: Astrasieversianin-VII
Category:  

Triterpenes other families Leguminosae Terpenoids Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields

Target:  

Others

Isoastragaloside II is an astragaloside, which is isolated from the hairy root culture of Astragalus membranaceus.
Brachyoside B
Brachyoside B
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Cat. No.: HY-N9989
CAS No.: 86764-12-7
Category:  

Leguminosae Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Saccharides Monosaccharides

Target:  

Others

Brachyoside B is a triterpenoid saponin from Astragalus wiedemannianus .
Rhamnocitrin 3-glucoside
Rhamnocitrin 3-glucoside
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Cat. No.: HY-N11472
CAS No.: 41545-37-3
Synonyms: Rhamnocitrin-3-O-β-D-glucopyranoside
Category:  

Flavonoids Leguminosae Flavones Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants

Target:  

Others

Rhamnocitrin 3-glucoside (Rhamnocitrin-3-O-β-D-glucopyranoside) is a natural product that can be isolated from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (AM) .
(R)-Mucronulatol
(R)-Mucronulatol
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Cat. No.: HY-N12954
CAS No.: 57128-11-7
Category:  

Monophenols Astragalus laxmannii Jacq. Leguminosae Phenols Plants

Target:  

Bacterial

(R)-Mucronulatol is a flavonoid that can be isolated from Astragalus adsurgens. (R)-Mucronulatol shows antibacterial activity against Escherichia coli, Bacillus cereus, Staphylococcus aureus, Erwinia carotovora and Bacillus subtili, with MICs of 15.5, 15.5, 7.8, 7.8, 15.5 μg/mL respectively .
Agroastragaloside I
Agroastragaloside I
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Cat. No.: HY-N10048
CAS No.: 156769-94-7
Category:  

Triterpenes Leguminosae Terpenoids Plants Astragalus membranaceus (Fisch.) Bunge

Target:  

Others

Agroastragaloside I is a astragaloside, and can be isolated from the hairy root cultures of Astragalus membranaceus .
Isomucronulatol 7-O-glucoside
Isomucronulatol 7-O-glucoside
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Cat. No.: HY-N6250
CAS No.: 136087-29-1
Synonyms: Isomucronulatol 7-O-β-glucoside
Category:  

Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants other families Flavonoids Monophenols Leguminosae Isoflavanones Phenols Disease Research Fields Inflammation/Immunology

Target:  

NO Synthase Interleukin Related

Isomucronulatol 7-O-glucoside (Isomucronulatol 7-O-β-D-glucoside) is an isoflavonoid glycoside isolated from the roots of Astragalus membranaceus. Isomucronulatol 7-O-glucoside targets inflammation-related pathways in vitro to exert anti-inflammatory activity without cytotoxicity at effective concentrations. Isomucucronulatol 7-O-glucoside inhibits NO production and weakly suppresses IL‑12 p40 production in vitro. Isomucronulatol 7-O-glucoside can be used for the research on inflammation .
Tamarixin
Tamarixin
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Cat. No.: HY-N9880
CAS No.: 27542-39-8
Category:  

Flavonoids Monophenols Leguminosae Flavones Phenols Plants Astragalus membranaceus (Fisch.) Bunge Saccharides Monosaccharides

Target:  

Bacterial

Tamarixin is flavonoid that isolated from Astragalus tanae Sosn that has hepatoprotective, antioxidant, anticancer, and antimicrobial activities .
Complanatoside A
Complanatoside A
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Cat. No.: HY-N0624
CAS No.: 146501-37-3
Category:  

Flavonols Flavonoids Papilionaceae Phenols Polyphenols Plants Disease Research Fields Astragalus complanatus Cancer

Target:  

Others

Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia.
Assay Types